®
Socket
Neuro-inhibitory Matrix
Handling/Anchoring Tab
Easy to Use
Renerva® PNM-CAP is designed with a socket to entubulate a nerve end and a handling/anchoring tab to ensure simple implantation.
Versatile
Renerva® PNM-CAP is available in multiple sizes and can be used for prevention or treatment of neuroma.
*Investigational Product
Highly Effective
Renerva® PNM-CAP's 3D neuro-inhibitory matrix prevents neuroma formation and pain (up to 17-fold reduction in nerve growth and 3.5-fold reduction in pain compared to standard of care controls).
1,2
RENERVA PNM-CAP
®
Clinical Problem
up to 48%
of leg amputations develop painful neuromas
Neuroma
Causes debilitating chronic pain, opioid use disorder, and a deep impact on quality of life
Mechanism of Action
Renerva® PNM-CAP can be easily connected to a nerve end via sutures.
Its neuro-inhibitory matrix allows limited and compartmentalized axonal growth.
Following complete device degradation/remodeling, the nerve end is encapsulated and stable with no further nerve growth.
Product Pipeline
PNM
Peripheral Nerve Matrix Hydrogel
Injectable Gel to improve nerve growth and functional recovery following nerve injury
PNM-G
Peripheral Nerve Matrix Graft
Nerve Conduit to bridge nerve gap injury
SND
Sutureless Neurorrhaphy Device
Device to obtain atraumatic nerve primary repair
References
1. Borcherding, S., Wood, M.D., Pinni, S.L. et al. Prevention of nerve growth and evoked pain with a nerve cap graft device. npj Regen Med 10, 29 (2025).
2. Faust, A. E., Soletti, L., Cwalina, N. A. et al. Development of an acellular nerve cap xenograft for neuroma prevention. Journal of biomedical materials research. Part A, 110(11), 1738–1748 (2022).